Specific inhibition of glucokinase by long chain acyl coenzymes A below the critical micelle concentration.
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چکیده
منابع مشابه
Specific inhibition of glucokinase by long chain acyl coenzymes A below the critical micelle concentration.
Rat liver glucokinase (EC 2.7.1.2) is inhibited specifically by the free form of palmitoyl-CoA (Ki apparent of approximately 1.8 PM) and other related long chain fatty acyl-CoAs under conditions where the micellar form of these compounds does not exist. This inhibition is instantaneous, and is immediately reversible by dilution, bovine serum albumin, and aor B-cyclodextrins. Inhibition is speci...
متن کاملAn allosteric model for the inhibition of glucokinase by long chain acyl coenzyme A.
Rat liver glucokinase is specifically inhibited by palmitoyl-CoA and other long chain acyl-CoAs at concentrations well below their critical micelle concentrations (Tippett, P. S., and Neet, K. E. (1982) J. Biol. Chem. 257, 12839-12845). Kinetic studies of this inhibition indicate that the long chain acyl-CoAs act on glucokinase through an allosteric site. The inhibition is competitive with both...
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Micelle formation in surfactant solutions is a self-assembly process governed by complex interplay of solvent-mediated interactions between hydrophilic and hydrophobic groups, which are commonly called heads and tails. However, the head-tail repulsion is not the only factor affecting the micelle formation. For the first time, we present a systematic study of the effect of chain rigidity on crit...
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Studies on acetyl-coenzyme A synthetase of yeast: inhibition by long-chain acyl-coenzyme A esters.
Long-chain acyl-coenzyme A (CoA) compounds (palmityl, stearyl, and oleyl) were found to be potent inhibitors of acetyl-CoA synthetase (ACS) of Saccharomyces cerevisiae strain LK2G12 from aerobic, but not from nonaerobic, cells. The effectiveness of the inhibitors of the aerobic enzyme was in the following order: palmityl-CoA < stearyl-CoA < oleyl-CoA. Short-chain acyl-CoA compounds (propionyl, ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1982
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)33591-9